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2′-Deoxyuridine

Name: 2&#8242;-Deoxyuridine
Brand: SIGMA

≥98.5%, synthetic (organic), powder

Synonym(s):

1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂N₂O₅

CAS Number:

951-78-0

Molecular Weight:

228.20

NACRES:

NA.51

PubChem Substance ID:

24893831

UNSPSC Code:

41106305

EC Number:

213-455-7

MDL number:

MFCD00006527

Beilstein/REAXYS Number:

24433

Assay:

≥98.5%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

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Properties

Product Name

2′-Deoxyuridine, ≥98.5%

biological source

synthetic (organic)

Quality Segment

300

assay

≥98.5%

form

powder

impurities

Thymidine, free

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

InChI key

MXHRCPNRJAMMIM-SHYZEUOFSA-N

Gene Information

mouse ... Slc29a1(63959)

Description

Application

2′-Deoxyuridine has been used as a:

precursor of [3H]thymidine triphosphate (TTP) in place of thymidine to avoid a potential thymidine block in relative proliferation assays
nucleoside supplement for cell cycle synchronization and DNA replication inhibition
mitotic inhibitor in culture media to minimize the proliferation of glial cells

Biochem/physiol Actions

2′-Deoxyuridine (dU) is frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogs of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU).

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This Item	B5002	B9285	10280879001
Sigma-Aldrich D5412 2′-Deoxyuridine	Sigma-Aldrich B5002 5-Bromo-2′-deoxyuridine	Sigma-Aldrich B9285 5-Bromo-2′-deoxyuridine	Roche 10280879001 5-Bromo-2′-deoxyuridine
description ≥98.5%	description ≥99% (HPLC)	description BioUltra, ≥99%	description >97%, crystalline solid, pkg of 1 g
biological source synthetic (organic)	biological source synthetic (organic)	biological source synthetic (organic)	biological source -
Quality Level 300	Quality Level 200	Quality Level 200	Quality Level -
form powder	form powder	form powder	form crystalline solid
assay ≥98.5%	assay ≥99% (HPLC)	assay ≥99%	assay >97%
solubility water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow	solubility DMSO: 50 mg/mL, clear, colorless to very faintly yellow	solubility NH₄OH: 0.1 M at 20 °C, clear, colorless	solubility -
impurities Thymidine, free	impurities -	impurities ≤0.1% Insoluble matter, ≤0.005% Phosphorus (P)	impurities -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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