Stephen J Pettitt et al.
Nature communications, 9(1), 1849-1849 (2018-05-12)
Although PARP inhibitors (PARPi) target homologous recombination defective tumours, drug resistance frequently emerges, often via poorly understood mechanisms. Here, using genome-wide and high-density CRISPR-Cas9 "tag-mutate-enrich" mutagenesis screens, we identify close to full-length mutant forms of PARP1 that cause in vitro
Haoyi Wang et al.
Cell, 153(4), 910-918 (2013-05-07)
Mice carrying mutations in multiple genes are traditionally generated by sequential recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a single mutation. The CRISPR/Cas system has been adapted as an efficient gene-targeting technology with the potential for
Ari E Friedland et al.
Nature methods, 10(8), 741-743 (2013-07-03)
We report the use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans germ line using single-guide RNAs that are expressed from a U6 small nuclear RNA promoter. Our results demonstrate
Le Cong et al.
Science (New York, N.Y.), 339(6121), 819-823 (2013-01-05)
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. We engineered two different
Marian L Burr et al.
Cancer cell, 36(4), 385-401 (2019-10-01)
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coordinated transcriptional silencing of the MHC-I antigen processing
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| CRISPR | 04061838113177 |
| CRISPRPL-1EA | 04061833541401 |
| HSOLIGOINT-1KT | 04061833826539 |
| PCRISPR002-1KT | 04065266925241 |
| PCRISPR001-1KT | 04065266925234 |
| HKCRISPR-1EA | 04061833813959 |
| CRISPR01-1SET | 04061833533802 |
| CRISPR02-1SET | 04061833533819 |
| PCRISPR003-1KT | 04065266925258 |
| PCRISPR007-1EA | 04065266925296 |
| PCRISPR008-1EA | 04065266925302 |
| PCRISPR004-1EA | 04065266925265 |
| CRISPR06-1EA | 04061833533826 |
| CRISPR07-1EA | 04061833533833 |
| CRISPR08-1EA | 04061833533840 |
| CAS9D10AMRNA-1EA | 04061833531495 |
| CAS9D10AP-1EA | 04061833531501 |
| CRISPR11-1EA | 04061833541265 |
| CRISPR12N-1EA | 04065269393337 |
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service