C6154

Z-Gln-Gly

γ-glutamyl donor substrate

• Synonym(s): N²-[(phenylmethoxy)carbonyl]-L-glutaminyl-glycine
• Empirical Formula (Hill Notation): C₁₅H₁₉N₃O₆
• CAS Number: 6610-42-0
• Molecular Weight: 337.33
• MDL number: MFCD00055926
• UNSPSC Code: 12352209
• PubChem Substance ID: 24892841
• NACRES: NA.26

Properties

• form: powder
• storage temp.: −20°C
• SMILES string: NC(=O)CCC(NC(=O)OCc1ccccc1)C(=O)NCC(O)=O
• InChI: 1S/C15H19N3O6/c16-12(19)7-6-11(14(22)17-8-13(20)21)18-15(23)24-9-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H2,16,19)(H,17,22)(H,18,23)(H,20,21)
• InChI key: SOUXAAOTONMPRY-UHFFFAOYSA-N

Description

Amino Acid Sequence

Z-Gln-Gly

Application

γ-Glutamyl donor substrate used in spectrophotometric determination of transglutaminase (TGase) activity. Z-Gln-Gly was used to enzymatically synthesize N-linked neoglycoproteins.

Biochem/physiol Actions

N-Benzyloxycarbonyl-L-Glutaminylglycine (Z-Gln-Gly, Z-QG) is used as a substrate to differentiate and characterize transglutaminase(s) (TGase) that catalyzes the post-translational covalent cross-linking of Gln- and Lys-containing peptides. Z-QG supports glutamyl-level cross-linking applications thruough surface modification.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves