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A7926

Sigma-Aldrich

Azlocillin sodium salt

Synonym(s):

D-α-([Imidazolidin-2-on-1-yl]carbonylamino)benzylpenicillin

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About This Item

Linear Formula:
C20H22N5O6SNa
CAS Number:
37091-65-9
Molecular Weight:
483.47
EC Number:
253-347-7
MDL number:
MFCD07793330
UNSPSC Code:
51282412
PubChem Substance ID:
24891295
NACRES:
NA.85
Pricing and availability is not currently available.

form

powder

Quality Level

200

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

room temp

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C20H23N5O6S.Na/c1-20(2)13(17(28)29)25-15(27)12(16(25)32-20)22-14(26)11(10-6-4-3-5-7-10)23-19(31)24-9-8-21-18(24)30;/h3-7,11-13,16H,8-9H2,1-2H3,(H,21,30)(H,22,26)(H,23,31)(H,28,29);/q;+1/p-1/t11-,12-,13+,16-;/m1./s1

InChI key

UVOCNBWUHNCKJM-XFAPPKAWSA-M

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General description

Chemical structure: ß-lactam

Application

Azlocillin is often used against <l>Pseudomonas aeruginosa </l>and has been used to develop novel antibiotic quantitation techniques [1].

Biochem/physiol Actions

Azlocillin is a semisynthetic penicillin and a β-lactam antibiotic. It acts by inhibition of penicillin-binding protein (PBP)-dependent bacterial cell wall synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Precautionary Statements

P280 - P302 + P352

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000209511
088M4854V
048M4883V
107M4756V
087M4858V

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A Weber et al.
Antimicrobial agents and chemotherapy, 24(5), 750-753 (1983-11-01)
We describe a rapid, precise, and simple procedure for the quantitation of azlocillin in serum and in aqueous solutions by high-pressure, reverse-phase liquid chromatography. This method uses a single precipitation step, detection by dual-wavelength monitoring (220 and 254 nm), and
Venkata Raveendra Pothineni et al.
Scientific reports, 10(1), 3798-3798 (2020-03-04)
Lyme disease is one of most common vector-borne diseases, reporting more than 300,000 cases annually in the United States. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. However, 10-20% of patients treated with antibiotic therapy
Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase.
Andrea M. Hujer, Malgosia Kania, et. Al
Journal of Affective Disorders, 49, 612-618 (2005)

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