07260

6-Aminohexanoic acid

≥98.5% (NT)

• Synonym(s): 6-Aminocaproic acid, 6-ACA, Aca, Acp, Aha, Ahx, acikaprin, afibrin, amicar, ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
• Linear Formula: H₂N(CH₂)₅CO₂H
• CAS Number: 60-32-2
• Molecular Weight: 131.17
• Beilstein: 906872
• EC Number: 200-469-3
• MDL number: MFCD00008238
• UNSPSC Code: 12352202
• PubChem Substance ID: 329748386
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98.5% (NT)
• mp: 207-209 °C (dec.) (lit.)
• SMILES string: NCCCCCC(O)=O
• InChI: 1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
• InChI key: SLXKOJJOQWFEFD-UHFFFAOYSA-N
• Gene Information: human ... PLAT(5327) , PLG(5340)

Description

General description

6-Aminohexanoic acid, or 6-aminocaproic acid, acts as an inhibitor of serine proteases.[1] It shares structural similarities with the natural amino acid lysine but lacks an α-amino group.[2]

Application

6-Aminohexanoic acid has been used as a component of the growth medium for tenogenic differentiation of mesenchymal stem cells.[3] It has also been used in the preparation of modified graphene quantum dots.[4]

Biochem/physiol Actions

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Other Notes

Improves solubilization of membrane proteins in electrophoresis[5]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): 404.6 - 408.2 °F
• Flash Point(C): 207 - 209 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves