B56412

Bromoacetyl bromide

≥98%

• Synonym(s): α-Bromoacetyl bromide, 2-Bromoacetyl bromide, Monobromoacetyl bromide
• Linear Formula: BrCH₂COBr
• CAS Number: 598-21-0
• Molecular Weight: 201.84
• Beilstein: 605440
• EC Number: 209-923-5
• MDL number: MFCD00000115
• UNSPSC Code: 12352100
• PubChem Substance ID: 24891846
• NACRES: NA.22

Properties

• vapor pressure: 3.8 mmHg ( 25 °C)
• Assay: ≥98%
• form: liquid
• refractive index: n20/D 1.547 (lit.)
• bp: 147-150 °C (lit.)
• density: 2.317 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: BrCC(Br)=O
• InChI: 1S/C2H2Br2O/c3-1-2(4)5/h1H2
• InChI key: LSTRKXWIZZZYAS-UHFFFAOYSA-N

Description

General description

Bromoacetyl bromide is employed as an acylating reagent and in the production of heterocyclic compounds.

Application

Bromoacetyl bromide can be used to convert:

• Amines to azido acetamides.
• p-Arsanilic acid to 4-(2-bromoacetylamino)benzenearsonic acid, a precursor to 4-(N-(S-penicillaminylacetyl)amino)phenylarsonous acid (PENAO), a metal-based drug.
• 3,5-Dimethylphenol to 3,5-dimethylphenyl 2-bromoacetate.
• Cystamine dihydrochloride to N,N′-bis(bromoacetyl) cystamine, a bifunctional quaternizing agent.

It can also be used as a reagent to synthesize imidazolium or piridinium based ionic liquids.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Skin Corr. 1B
• Supplementary Hazards: EUH014
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 221.0 °F - closed cup
• Flash Point(C): 105 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves