349119
1-Phenylisatin
97%
Synonym(s):
1-Phenyl-2,3-indolinedione, NSC 100013
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About This Item
Empirical Formula (Hill Notation):
C14H9NO2
CAS Number:
Molecular Weight:
223.23
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
97%
mp
138-140 °C (lit.)
functional group
ketone
SMILES string
O=C1N(c2ccccc2)c3ccccc3C1=O
InChI
1S/C14H9NO2/c16-13-11-8-4-5-9-12(11)15(14(13)17)10-6-2-1-3-7-10/h1-9H
InChI key
UWCPWBIMRYXUOU-UHFFFAOYSA-N
General description
1-Phenylisatin is an isatin. It is a potential anticancer, anti-HIV drug. Its binding interaction with a model transport protein bovine serum albumin (BSA) has been investigated using fluorescence spectroscopic technique.[1] Interactions between human adult hemoglobin (Hb) and 1-phenylisatin has been investigated by steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR and anisotropy.[2]
Application
Reactant for preparation of:
- Indolin-2,3-dione Schiff bases as potential antimycobacterial agents
- Antipyretic agents
- Antiproliferative agents
- Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic Pain
- Phenylacetamides as anticonvulsant agents
- Selective Galanin GAL3 Receptor Antagonists
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Bijan Kumar Paul et al.
Physical chemistry chemical physics : PCCP, 15(4), 1275-1287 (2012-12-13)
The present contribution reports a detailed characterization of the binding interaction of a potential anticancer, anti-HIV drug 1-phenylisatin (1-PI) with a model transport protein Bovine Serum Albumin (BSA) using fluorescence spectroscopic techniques. The thermodynamic parameters e.g., ΔH, ΔS and ΔG
Puspita Sahu et al.
Psychopharmacology, 236(6), 1829-1838 (2019-01-23)
Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression. Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system. The present study was aimed
Paulami Mandal et al.
The journal of physical chemistry. B, 113(45), 14904-14913 (2009-10-13)
In this report, steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR, and anisotropy investigations were made to reveal the nature of the interactions between human adult hemoglobin (Hb) and the isatins, 1-methylisatin (1-MI) and 1-phenylisatin (1-PI).
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