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329061

Sigma-Aldrich

2-Mercaptopyridine N-oxide sodium salt

95%

Synonym(s):

1-Oxo-2-pyridinethiol sodium salt, 2-Pyridinethiol N-oxide sodium salt, Sodium (2-pyridylthio-1-oxide), Sodium 2-mercaptopyridine 1-oxide, Sodium 2-mercaptopyridine N-oxide

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About This Item

Empirical Formula (Hill Notation):
C5H4NNaOS
CAS Number:
Molecular Weight:
149.15
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

95%

solubility

water: soluble 0.5 g/10 mL, clear, colorless to light yellow

SMILES string

O.[O-][n+]1ccccc1S[Na]

InChI

1S/C5H5NOS.Na/c7-6-4-2-1-3-5(6)8;/h1-4,8H;/q;+1/p-1

InChI key

WNGMMIYXPIAYOB-UHFFFAOYSA-M

General description

2-Mercaptopyridine N-oxide acts as labelling agent during indium-111 labelling of human platelets. It acts as bioactive ligand and forms palladium and platinum complexes, which were tested as potential antitrypanosomal agents.

Application

For chemistry of 2-mercaptopyridine-N-oxide, see Aldrichimica Acta.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1

Target Organs

Nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marisol Vieites et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 13(5), 723-735 (2008-03-07)
In the search for new therapeutic tools against Chagas disease (American trypanosomiasis) palladium and platinum complexes of the bioactive ligand pyridine-2-thiol N-oxide were exhaustively characterized and evaluated in vitro. Both complexes showed high in vitro growth inhibition activity (IC(50) values
Y Isaka et al.
European journal of nuclear medicine, 18(5), 326-331 (1991-01-01)
Human platelets were labelled in the absence or presence of plasma using indium-111 labelled oxine sulphate, tropolone or 2-mercaptopyridine-N-oxide (MPO). Under in vitro and in vivo conditions, platelet functions were evaluated by measuring their aggregability, survival, recovery and early distribution.
Aldrichimica Acta, 20, 35-35 (1987)

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