This is not an application that is tested internally, but there is evidence in literature (Iwunze MO. The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX). Material Sci & Eng. 2022;6(3):97‒99. DOI: 10.15406/mseij.2022.06.00185) that concentrations between 6.45 x 10-7 M to 3.24 x 10-6 M PPIX are effective for quenching. Another author describes the quenching of protein fluorescence by PPIX by using a solution concentration range of 1×10−5 M to 3×10−4 M excited at 280 nm and 1x10−5 M to 3×10−4 M excited at 295 nm (Characteristics of the Protoporphyrin IX Binding Sites on Human Serum Albumin Using Molecular Docking, Molecules 2016, 21(11), 1519).
258385
Protoporphyrin IX disodium salt
≥90% (HPLC)
Synonym(s):
3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid disodium salt, Depocolin-S, Ooporphyrin disodium salt
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About This Item
Empirical Formula (Hill Notation):
C34H32N4Na2O4
CAS Number:
Molecular Weight:
606.62
Beilstein:
5227034
EC Number:
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
NACRES:
NA.23
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Quality Level
Assay
≥90% (HPLC)
form
powder
λmax
406 nm
storage temp.
2-8°C
SMILES string
[Na+].[Na+].Cc1c(CCC([O-])=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC([O-])=O
InChI
1S/C34H34N4O4.2Na/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16,36-37H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);;/q;2*+1/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
InChI key
JZRNDUPVNXWZDY-HXFTUNQESA-L
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Pan Wang et al.
Ultrasonics, 53(5), 935-942 (2013-02-19)
Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in
Agata Nowak-Stępniowska et al.
Acta biochimica Polonica, 59(4), 603-611 (2012-11-29)
Mitochondria are cell energetic centers where ATP is produced. They also play a very important role in the PDT as intracellular sites of photosensitizer localization. Photosensitizers gathering in mitochondria (like porphyrin derivatives used in this work) are more effective in
Filipa L Sousa et al.
Genome biology and evolution, 5(1), 200-216 (2012-12-22)
An open question regarding the evolution of photosynthesis is how cyanobacteria came to possess the two reaction center (RC) types, Type I reaction center (RCI) and Type II reaction center (RCII). The two main competing theories in the foreground of
Leng-Yin Wang et al.
Nanoscale, 5(1), 416-421 (2012-11-29)
Various nanocarriers for photosensitizers have been developed to solve the problems of limiting the clinical utility of photodynamic therapy (PDT); however, to date, no carriers capable of supplying oxygen have been reported. We reported the development of a novel system
Woo Hyung Lee et al.
Chemico-biological interactions, 204(1), 49-57 (2013-04-30)
Porphyrins are used for photodynamic therapy for their light-absorbing properties, and some of them were approved for the treatment of certain types of cancers. Porphyrins prevent activation of hypoxia inducible factor-1α (HIF-1α) by inhibiting heat shock protein 90 (HSP90). This
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To study interaction of porphyrin with a protein, how should a solution of this compound be made for flourescence quenching?
1 answer-
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What is the water solubility of PPIX-disodium?
1 answer-
This chemical is known to be soluble in chloroform or methanol and slightly soluble in water. The concentration at which this product is solubilized is not determined.
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