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USP

Butylated hydroxytoluene

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Linear Formula:
[(CH3)3C]2C6H2(CH3)OH
CAS Number:
128-37-0
Molecular Weight:
220.35
Beilstein:
1911640
EC Number:
204-881-4
MDL number:
MFCD00011644
UNSPSC Code:
41116107
PubChem Substance ID:
329749182
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

API family

butylated hydroxytoluene

autoignition temp.

878 °F

manufacturer/tradename

USP

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Butylated hydroxytoluene USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Dutasteride and Tamsulosin Hydrochloride Capsules

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

260.6 °F - open cup

Flash Point(C)

127 °C - open cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Butylated Hydroxytoluene
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(6), 5652-5652 (2021)
Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene.
A L Branen
Journal of the American Oil Chemists' Society, 52(2), 59-63 (1975-02-01)
Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).
H Witschi et al.
Pharmacology & therapeutics, 42(1), 89-113 (1989-01-01)
Krzysztof Kurek et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1074-1083 (2013-10-11)
Nonalcoholic fatty liver disease (NAFLD) is an insulin resistance-related hepatic disorder which can transform to cirrhosis. Insulin resistance deregulates hepatic lipid metabolism, leading to accumulation of cytotoxic lipids including ceramide and diacylglycerols. Myriocin, obtained from fungi traditionally used in Chinese
E M Bomhard et al.
Mutation research, 277(3), 187-200 (1992-09-01)
Butylated hydroxytoluene (BHT) is an effective, widely used, low cost antioxidant. A host of studies examining the potential of BHT to cause point mutations have been published. They include in vitro studies on various bacterial species and strains and on
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