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T8931
Thyrotropic hormone from bovine pituitary
Synonym(s):
TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
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About This Item
Pricing and availability is not currently available.
biological source
bovine pituitary glands
Quality Segment
form
powder
packaging
vial of 100 μg
technique(s)
cell culture | mammalian: suitable
storage temp.
2-8°C
Gene Information
cow ... TSHB(281552)
human ... TSHR(7253)
General description
Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.
Application
Thyrotropic hormone from bovine pituitary has been used:
- to induce cAMP production in orbital fibroblasts.
- as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
- for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.[1]
- for studying the thyrotropin involvement in photoperiodic signal transduction in mice.[2]
Biochem/physiol Actions
Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.[3]
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Analysis Note
Contains phosphate buffer salts
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This Item | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) activity assay: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| biological source bovine pituitary glands | biological source human | biological source bovine pituitary glands | biological source bovine pituitary glands |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form lyophilized powder | form lyophilized powder |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information cow ... TSHB(281552) | Gene Information human ... TRH(7200), TRHR(7201) | Gene Information bovine ... FGF2(281161) | Gene Information - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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こちらの製品の使用期限を教えてください。 製品：T8931-10VL Source：SLCL1077 よろしくお願いいたします。
1 answer-
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Without IU, what concentration in mg/ml is typically used in thyroid cell culture?
1 answer-
Historically, the activity of this product was determined to have a range of 1.5 - 2.5 IU/mg protein. This product has not been screened for activity for a number of years. There are publications citing the use of bovine TSH in uM concentrations. Please see the link below to review an example:
https://www.ahajournals.org/doi/pdf/10.1161/01.atv.0000102520.84030.a1To review a sample Certificate of Analysis for this product, please see the link below:
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/T8931-BULK0000257036.pdfAlternatively, product T9265, a human source TSH, is tested for unit activity. Should this product be of interest, please see the link below:
https://www.sigmaaldrich.com/product/sigma/t9265Helpful?
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Which is the units content of 100 ug of this product? thank you very much
1 answer-
The unit activity for item T8931, Thyrotropic hormone from bovine pituitary, is not specified.
Helpful?
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