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SML0679

Sigma-Aldrich

Danshensu sodium salt

≥98% (HPLC)

Synonym(s):

(R)-α,3,4-Trihydroxy-benzenepropanoic acid sodium salt, (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid, 3-(3′,4′-Dihydroxyphenyl)-(2R)-lactic acid sodium salt, DS 182, Dan Shen Su, Dan shen suan A, Salianic acid A, Salvianic acid A

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About This Item

Empirical Formula (Hill Notation):
C9H9O5 · Na
CAS Number:
81075-52-7
Molecular Weight:
220.15
MDL number:
MFCD07781415
UNSPSC Code:
12352200
PubChem Substance ID:
329825582
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +30 to +40°, c = 1 in H2O

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(O)C=CC(C[C@@H](O)C([O-])=O)=C1.[Na+]

InChI

1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1/t8-;/m1./s1

InChI key

ZMMKVDBZTXUHFO-DDWIOCJRSA-M

Biochem/physiol Actions

Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia. Danshensu is cardioprotective, which protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jian-ping Zhang et al.
Planta medica, 79(9), 744-752 (2013-05-24)
The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), first recorded in the "Shen Nong's Herbal Classic", has long been used to treat cardiovascular conditions, although the mechanism(s) underlying its effects remain unclear. Here, an iron dextran injection (50 mg ·
Ye Jin et al.
Journal of pharmaceutical and biomedical analysis, 77, 32-39 (2013-01-30)
The application of near infrared (NIR) spectroscopy for on-line quantitative monitoring of alcohol precipitation of the Danhong injection was investigated. For the NIR measurements, two fiber optic probes designed to transmit NIR radiation through a 2mm path length flow cell
Libo Du et al.
Nanotoxicology, 7(3), 294-300 (2012-02-09)
To suppress the cytotoxicity of gold nanoparticles (AuNPs), danshensu, a naturally occurring polyphenol antioxidant isolated from Chinese herb, was used to provide a fundamental protection layer for AuNPs, to alleviate oxidative stress and as a reducing agent to react with
Limin Zhou et al.
Journal of ethnopharmacology, 143(2), 648-655 (2012-08-08)
Danshen-Gegen (DG) product has clinically been proven to be an effective agent for heart-tonic efficacy by our previous research. In the mean time, herb-drug interactions between DG product and its commonly co-administered drugs, such as aspirin or warfarin need to
Li-Long Pan et al.
Biochimica et biophysica acta, 1830(4), 2861-2871 (2013-01-19)
Heme oxygenase-1 (HO-1) has potential anti-apoptotic properties. A novel compound [4-(2-acetoxy-3-((R)-3-(benzylthio)-1-methoxy-1-oxopropan-2- ylamino)-3-oxopropyl)-1,2-phenylene diacetate (DSC)] was synthesized by joining danshensu and cysteine through an appropriate linker. This study investigated if the cytoprotective properties of DSC involved the induction of HO-1. We
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