O1012
Oleoyl coenzyme A lithium salt
≥90% (HPLC)
Synonym(s):
cis-9-Octadecenoyl coenzyme A
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About This Item
Empirical Formula (Hill Notation):
C39H68N7O17P3S
CAS Number:
Molecular Weight:
1031.98
NACRES:
NA.51
UNSPSC Code:
41106305
Form:
powder
Assay:
≥90% (HPLC)
Solubility:
H2O: soluble-50 mg/mL, clear, colorless
Quality Level
assay
≥90% (HPLC)
form
powder
solubility
H2O: soluble-50 mg/mL, clear, colorless
storage temp.
−20°C
Application
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Oleoyl coenzyme A (Oleoyl-CoA) may be used to study the specificity and kinetics of enzymes such as acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) involved in long chain fatty acid cholesterol esterification.
Biochem/physiol Actions
Oleoyl-CoA is an important substrate, that is essential for the biosynthesis of 1-Alkyl-2,3-diacylglycerol (ADG) and very long chain monounsaturated fatty acids of harderian gland (HG) 1-alkyl-2,3-diacylglycerol.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Mariana Igoillo-Esteve et al.
International journal for parasitology, 41(3-4), 429-438 (2010-12-18)
Metabolism in trypanosomatids is compartmentalised with major pathways, notably glycolysis, present in peroxisome-like organelles called glycosomes. To date, little information is available about the transport of metabolites through the glycosomal membrane. Previously, three ATP-binding cassette (ABC) transporters, called GAT1-3 for
Chengcheng Guan et al.
Nature communications, 11(1), 2478-2478 (2020-05-20)
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage. SOAT1 is a target to treat several
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs.
Leon C, Hill JS, Wasan KM.
Pharmaceut. Res., 22, 1578-1588 (2005)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| O1012-10MG | 04061834213031 |
| O1012-5MG | 04061834213048 |