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HPA028850

Sigma-Aldrich

Anti-TFAP2A antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-AP-2, Anti-AP2TF, Anti-BLTR, Anti-CMKRL1, Anti-GPR16, Anti-LTB4R1, Anti-P2RY7, Anti-P2Y7, Anti-TFAP2, Anti-transcription factor AP-2 α (activating enhancer binding protein 2 α)

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.43

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

rat, human

enhanced validation

orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:1000-1:2500

immunogen sequence

RHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKD

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TFAP2A(7020)

General description

The gene TFAP2A (transcription factor AP-2-α) is mapped to human chromosome 6p24.3. It is a transcription factor. The protein has a helix-span-helix motif for DNA binding. TFAP2A protein can bind to G/C-rich elements. It belongs to the AP-2 transcription factor family of proteins.

Immunogen

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-TFAP2A antibody produced in rabbit has been used as a capturing agent for immunoenrichment coupled mass spectrometry.

Biochem/physiol Actions

TFAP2A (transcription factor AP-2-α) is involved in development, apoptosis and cell cycling, and oncogenesis. It is upregulated in presence of Hepatitis B virus X and is responsible for hepatoma cell growth. Changes in the expression of this gene are linked with various cancers, such as melanoma, prostate, breast, ovarian, gastric, colon and bladder cancers. TFAP2A controls expression of genes associated with proliferation (c-MYC), cell cycle (HER-2 (receptor tyrosine-protein kinase) and p21WAF1 (cyclin-dependent kinase inhibitor 1)), cell death (c-KIT (tyrosine-protein kinase), Bcl-2 (B-cell lymphoma 2), and FAS (tumor necrosis factor receptor superfamily member)), cell attachment (MUC18 (melanoma-associated antigen) and E-cadherin), and tumor invasion/angiogenesis (MMP-9 (matrix metalloproteinase), PAI-I (plasminogen activator inhibitor), and PAR-1 (protease-activated receptor)). Mutations in this gene are associated with branchio-oculo-facial syndrome.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST77632

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor.
Murata T, et al.
Journal of Virology, 90, 3873-3889 (2016)
EYA1-related disorders: two clinical cases and a literature review.
Castiglione A, et al.
International Journal of Pediatric Otorhinolaryngology, 78, 1201-1210 (2014)
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2a and sphingosine kinase 1.
Lu ZP, et al.
Acta Pharmacologica Sinica, 36, 1228-1236 (2015)
Ectopic expression of AP-2a transcription factor suppresses glioma progression.
Su W, et al.
International Journal of Clinical and Experimental Pathology, 7, 8666-8674 (2014)
A clinical and molecular analysis of branchio-oculo-facial syndrome patients in Russia revealed new mutations in TFAP2A.
Meshcheryakova TI, et al.
Annals of Human Genetics, 79, 148-152 (2015)

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