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The molecular weight for this product is not determined. It is considered to be a cross-linked form. Various publications site this type of fibrin having a ranging anywhere from 80kDa to 300kDa or more.
F5386
Fibrin from human plasma
insoluble powder
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About This Item
Form:
powder
Biological source:
human plasma
Pricing and availability is not currently available.
biological source
human plasma
Quality Segment
form
powder
technique(s)
indirect ELISA: suitable
SMILES string
N(CC(=O)NC)C(=O)CN
InChI
1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)
InChI key
BWGVNKXGVNDBDI-UHFFFAOYSA-N
General description
Fibrin is produced from cross-linking of fibrinogen by thrombin. Fibrinogen is made up of two monomers each containing three polypeptide chains. Fibrinogen is a major plasma protein.
Application
Fibrin from human plasma has been used:
- for in vitro cleavage of fibrinogen and fibrin
- as a reference for true component analysis (TCA) and principal component analysis (PCA) of Raman spectra
- as a reference in Raman spectroscopy to study the binding mechanisms and the binding efficiency of the different polyoxometalates (POMs)
Biochem/physiol Actions
Fibrin acts as an important bio-polymer in the primary blood clotting process. It creates a scaffold for infiltrating cells during tissue repair. Fibrin is widely used as a tissue sealant for tissue regeneration applications as it enables the formation of a biocompatible physical structure. It is also used in delivery systems for cells and bioactive molecules. The fibrin matrix resembles the native pancreas and can serve as a scaffold material for islet transplantation. Fibrin has been used in studies to obtain fibrin-specific monoclonal antibodies (mAbs). These mAbs may be used to determine their role in fibrin polymerization and use in fibrin quantification in blood plasma.
Preparation Note
Prepared by clotting fibrinogen to yield a crosslinked fibrin
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| technique(s) indirect ELISA: suitable | technique(s) cell culture | mammalian: suitable | technique(s) LC/MS: suitable, electrophoresis: suitable | technique(s) - |
| biological source human plasma | biological source bovine plasma | biological source human | biological source human |
| form powder | form powder | form powder | form lyophilized |
| Gene Information human ... FGA(2243), FGB(2244), FGG(2266) | Gene Information cow ... FGA(522039), FGB(510522), FGG(280792) | Gene Information human ... FGB(2244) | Gene Information human ... F2(2147) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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hi, I wonder what's the molecular mass of the fibrin you provide. I would appreciate it if you can offer me answer as soon as possible.
1 answer-
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