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F3388

Sigma-Aldrich

Ferric citrate

BioReagent, suitable for cell culture

Synonym(s):

Iron(III) citrate, Iron(III) citrate hydrate

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About This Item

Empirical Formula (Hill Notation):
C6H5FeO7
CAS Number:
3522-50-7
Molecular Weight:
244.94
EC Number:
222-536-6
MDL number:
MFCD00013098
UNSPSC Code:
12352205
PubChem Substance ID:
24894843
NACRES:
NA.75

biological source

synthetic (organic)

product line

BioReagent

technique(s)

cell culture | mammalian: suitable

solubility

hot water: 0.01 g/mL, clear, orange-yellow

shipped in

ambient

storage temp.

room temp

SMILES string

OC12CC(=O)O[Fe](OC(=O)C1)OC2=O

InChI

1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3

InChI key

NPFOYSMITVOQOS-UHFFFAOYSA-K

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Application

Ferric citrate provides a source of iron used in cell culture applications. It provides iron in a less toxic form than free iron salts. Ferric citrate has been used as medium supplement in human osteosarcoma cell (U2OS) culture, human embryonic kidney (HEK293) cells and adult primary cardiomyocytes.

Biochem/physiol Actions

Ferric citrate is used as a component of protein-free medium. It is used as a substitute for transferrin in mouse hybridomas culture. Ferric citrate enhances IgM production. It indirectly stimulates the mitogen-activated protein kinase (MAPK) by favoring high amphiregulin oncoprotein levels in colon cancer.  Ferric citrate is effective in binding to phosphate in patients with dialysis-dependent chronic kidney disease.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development of a protein-free medium with iron salts replacing transferrin for a human-human hybridoma
Nagira K, et al.
Bioscience, Biotechnology, and Biochemistry, 59(4), 743-745 (1995)
Nonantibiotic effects of fluoroquinolones in mammalian cells
Badal S, et al.
The Journal of Biological Chemistry, 290(36), 22287-22297 (2015)
Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells
Scheers NM, et al.
Oncotarget, 9(24), 17066-17066 (2018)
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis
Lakhal-Littleton S, et al.
eLife, 5, e19804-e19804 (2016)
Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease
Chertow GM, et al.
PLoS ONE, 12(11), e0188712-e0188712 (2017)
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