C8221

Caffeic acid phenethyl ester

synthetic, ≥97% (HPLC), Nuclear transcription factor NF-κB inhibitor, powder

• Synonym(s): CAPE
• Empirical Formula (Hill Notation): C₁₇H₁₆O₄
• CAS Number: 104594-70-9
• Molecular Weight: 284.31
• UNSPSC Code: 12352108
• PubChem Substance ID: 24278341
• NACRES: NA.77
• MDL number: MFCD00866470
• Assay: ≥97% (HPLC)
• Form: powder
• Quality level: 200
• Storage condition: protect from light

Properties

• Product Name: Caffeic acid phenethyl ester, ≥97% (HPLC), powder
• biological source: synthetic
• Quality Level: 200
• assay: ≥97% (HPLC)
• form: powder
• storage condition: protect from light
• color: off-white
• solubility: ethyl acetate: 50 mg/mL, DMSO: soluble, ethanol: soluble
• storage temp.: −20°C
• SMILES string: Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O
• InChI: 1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
• InChI key: SWUARLUWKZWEBQ-VQHVLOKHSA-N
• Gene Information: human ... NFKB2(4791)

Description

Application

Caffeic acid phenethyl ester (CAPE) has been used to determine the effect of CAPE in hyperthyroidism, as a component of culture media to measure the cytotoxicity of breast cancer cell line MDA-MB-231, to study its effects on amiodarone-induced pulmonary fibrosis in rats.

Biochem/physiol Actions

Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.

CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves