B8041
Biglycan from bovine articular cartilage
essentially salt-free, lyophilized powder
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About This Item
Form:
essentially salt-free, lyophilized powder
Biological source:
bovine articular cartilage
Mol wt:
200-350 kDa
biological source
bovine articular cartilage
Quality Segment
form
essentially salt-free, lyophilized powder
mol wt
200-350 kDa
packaging
glass bottle of 0.5 mg
technique(s)
cell culture | mammalian: suitable
solubility
water: soluble ≥2.00 mg/mL, clear, colorless
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
cow ... BGN(280733)
General description
proteoglycan consisting of a 45 kDa core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains
Biochem/physiol Actions
Biglycan interacts with collagen type I and II, fibronectin and TGF-β. In a low ionic strength (less than 3 mM phosphate) buffer, Biglycan binds more strongly to collagen type I. At higher ionic strengths, Biglycan will instead increase the inhibition effect of TGF-β on osteoclast proliferation at a concentration of 4-20 mg/mL. It also functions to prevent the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/mL. As an extracellular component, Biglycan binds TGF-β 1, facilitates bone mineralization and supports osteoblast differentiation thru BMP-4 binding.
Preparation Note
This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.
Other Notes
Biglycan is a 200-350 kDa proteoglycan consisting of a 45 kDa core protein and two chondroitin/dermatan sulfate glycosaminoglycan chains.
Disclaimer
Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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