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5-(N,N-Dimethyl)amiloride hydrochloride

Name: 5-(<I>N</I>,<I>N</I>-Dimethyl)amiloride hydrochloride
Brand: SIGMA

cAMP-dependent protein kinase inhibitor, powder

Synonym(s):

3-Amino-N-(aminoiminoethyl)-5-(dimethylamino)-6-chloropyrazinecarboxamide hydrochloride, DMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₂ClN₇O · HCl

CAS Number:

1214-79-5

Molecular Weight:

294.14

UNSPSC Code:

12352200

PubChem Substance ID:

24278216

NACRES:

NA.77

MDL number:

MFCD00069207

Form:

powder

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Properties

Product Name

5-(N,N-Dimethyl)amiloride hydrochloride,

form

powder

Quality Segment

200

storage temp.

2-8°C

SMILES string

Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N

InChI

1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

InChI key

IIUPTHVVXMBJMQ-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)

Description

Application

5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na²/H⁺ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.

Biochem/physiol Actions

Selective blocker of Na⁺/H⁺ antiport; IC₅₀ = 6.9 μM.

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This Item	A7410	SML0574	M9656
Sigma-Aldrich A4562 5-(N,N-Dimethyl)amiloride hydrochloride	Sigma-Aldrich A7410 Amiloride hydrochloride hydrate	Sigma-Aldrich SML0574 YM-298198 hydrochloride	Sigma-Aldrich M9656 H-8 dihydrochloride
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level -
storage temp. 2-8°C	storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C
Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548) mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)	Gene Information human ... ABP1(26), ACCN1(40), ACCN2(41), PLAU(5328), SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), TNF(7124) mouse ... Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544) rat ... Abp1(65029), Accn1(25364), Accn2(79123), Plau(25619), Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782)	Gene Information -	Gene Information human ... CALCRL(10203), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577) rat ... Calcrl(25029)

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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