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Aprotinin

Name: Aprotinin
Brand: SIGMA

3-7 TIU/mg solid, lyophilized powder

Synonym(s):

BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

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About This Item

Empirical Formula (Hill Notation):

C₂₈₄H₄₃₂N₈₄O₇₉S₇

CAS Number:

9087-70-1

Molecular Weight:

6511.44

UNSPSC Code:

12352202

NACRES:

NA.54

EC Number:

232-994-9

MDL number:

MFCD00130541

eCl@ss:

32190102

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Properties

Product Name

Aprotinin from bovine lung, lyophilized powder, 3-7 TIU/mg solid

biological source

bovine lung

Quality Segment

300

form

lyophilized powder

specific activity

3-7 TIU/mg solid

mol wt

~6,500

solubility

H₂O: >10 mg/mL

UniProt accession no.

P00974

storage temp.

2-8°C

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Gene Information

cow ... PTI(404172)

Description

Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Preparation Note

This product is an affinity purified lyophilized powder purified to remove trace impurities. It has an activity of 3-7 TIU/mg.

Other Notes

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

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1 of 1

This Item	A1153	A3428	10820
Sigma-Aldrich A4529 Aprotinin from bovine lung	Sigma-Aldrich A1153 Aprotinin from bovine lung	Sigma-Aldrich A3428 Aprotinin from bovine lung	Sigma-Aldrich 10820 Aprotinin from bovine lung
biological source bovine lung	biological source bovine lung	biological source bovine lung	biological source bovine lung
Gene Information cow ... PTI(404172)	Gene Information cow ... PTI(404172)	Gene Information cow ... PTI(404172)	Gene Information cow ... PTI(404172)
Quality Level 300	Quality Level 300	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form crystalline (fine)
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: >10 mg/mL	solubility H₂O: ≥5 mg/mL	solubility H₂O: 5 mg/mL	solubility phosphate buffer: 5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate))

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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