A2580
Angiotensin Converting Enzyme from porcine kidney
lyophilized powder, ≥10 units/mg protein (Bradford)
Synonym(s):
ACE, Peptidyl-dipeptidase A
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About This Item
CAS Number:
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
eCl@ss:
42010109
Specific activity:
≥10 units/mg protein (Bradford)
Pricing and availability is not currently available.
form
lyophilized powder
Quality Segment
specific activity
≥10 units/mg protein (Bradford)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
pig ... ACE(613133)
General description
Angiotensin converting enzyme (ACE) is encoded by the gene, mRNA-decapping enzyme subunit 1 (DCP1). It is a zinc metalloprotease, which belongs to the M2 family.
ACE is a monomer with molecular weight of ~170 kDa
pH range for activity: 7-8.5
Temperature optimum: 37 °C
Zinc is required for activity
Inhibitors: captopril, enalaprilat, lisinopril etc. (1-10 μM)
pH range for activity: 7-8.5
Temperature optimum: 37 °C
Zinc is required for activity
Inhibitors: captopril, enalaprilat, lisinopril etc. (1-10 μM)
Application
Angiotensin converting enzyme from porcine kidney has been used in in vitro angiotensin-converting enzyme (ACE) inhibition assay.
Biochem/physiol Actions
Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II, which regulates the fluid-electrolyte balance and systemic blood pressure. ACE inhibits the vasodilator, bradykinin. ACE inhibitors are used to treat high blood pressure.
Removes C-terminal dipeptides from susceptible substrates, e.g., angiotensin I and bradykinin.
Physical form
Lyophilized powder containing Tris buffer salts.
Other Notes
One unit will produce 1.0 ·μmole of hippuric acid from Hippuryl-His-Leu per min in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37 °C.
1 of 1
This Item | |||
|---|---|---|---|
| Gene Information pig ... ACE(613133) | Gene Information - | Gene Information - | Gene Information pig ... ACY1(396930) |
| specific activity ≥10 units/mg protein (Bradford) | specific activity ≥2.0 units/mg protein (modified Warburg-Christian) | specific activity ≥10 U/mg | specific activity ≥1500 units/mg protein |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in - |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. | UniProt accession no. |
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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