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82934

Sigma-Aldrich

7-Hydroxycitronellal

Odorant used in allergy studies

Synonym(s):

7-Hydroxy-3,7-dimethyloctanal, Citronellal hydrate

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About This Item

Empirical Formula (Hill Notation):
C10H20O2
CAS Number:
107-75-5
Molecular Weight:
172.26
EC Number:
203-518-7
MDL number:
MFCD00014681
UNSPSC Code:
12352200
PubChem Substance ID:
57652938
NACRES:
NA.52

grade

for molecular biology

Assay

≥95.0% (GC)

form

powder

density

0.92 g/mL at 20 °C (lit.)

storage temp.

room temp

SMILES string

[H]C(CC(C)CCCC(O)(C)C)=O

InChI

1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3

InChI key

WPFVBOQKRVRMJB-UHFFFAOYSA-N

General description

7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.

Application

Suitable for
  • contact sensitization studies to identify allergens present in cosmetic preparations
  • elucidation of molecular pathways related to allergic reactions
  • analytical standard

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
H Wahlkvist et al.
Contact dermatitis, 41(4), 198-206 (1999-10-09)
A multi-dose-response induction protocol for the guinea pig maximization test (GPMT), including a statistical computer program, has earlier been developed to improve the power of predictive tests for identification of contact allergens. This dose-response protocol, with 2 modifications (i.e., increased
R A Ford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(11-12), 921-926 (1988-11-01)
Hydroxycitronellal, an important ingredient in fragrances, was studied for its sensitizing potential in human skin. Fifteen human maximization tests were conducted with hydroxycitronellal obtained from four different sources at induction concentrations from 5 to 12%. No reactions were induced at
S Heydorn et al.
Contact dermatitis, 49(3), 133-139 (2003-12-18)
Household and cleaning products often contain both allergens and irritants. The aim of this double-blinded, randomized, paired study was to determine whether patch testing with an allergen (hydroxycitronellal) combined with an irritant [sodium lauryl sulfate (SLS)] cause a stronger patch
Clarissa D Villarama et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(11), 1719-1725 (2004-09-08)
The clinical relevance of patch test reactions is often difficult to determine. Use tests have been developed to further evaluate the significance of patch test results. We review studies that have defined correlations between the threshold concentrations at patch testing
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