T0397

L-Thyroxine sodium salt pentahydrate

γ-irradiated, powder, BioXtra, suitable for cell culture

• Synonym(s): 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T₄
• Linear Formula: HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa · 5H₂O
• CAS Number: 6106-07-6
• Molecular Weight: 888.93
• Beilstein: 5721845
• EC Number: 200-221-4
• MDL number: MFCD00149110
• UNSPSC Code: 12352209
• PubChem Substance ID: 24899887
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• sterility: γ-irradiated
• product line: BioXtra
• Assay: ≥98%
• form: powder
• potency: 5-50 ng/mL
• technique(s): cell culture | mammalian: suitable
• mp: 207-210 (dec.) (lit.)
• solubility: cell culture medium: 0.1 mg/mL; H₂O: soluble
• storage temp.: −20°C
• SMILES string: O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1
• InChI key: JMHCCAYJTTWMCX-QWPJCUCISA-M
• Gene Information: mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Description

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstitution

To prepare 20 μg/ml stock solution, add 50 ml sterile culture medium.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H372
• Precautionary Statements: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• Target Organs: Thyroid,Cardio-vascular system,Kidney
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves