SML3765

ISA-2011B

≥97% (HPLC)

• Synonym(s): rel-(5R,10aR)-5-(5-Chloro-1H-indol-3-yl)-8,9,10a,11-tetrahydro-9-methyl-5H-1,3-dioxolo[4,5-g]pyrazino[1,2-b]isoquinoline-7,10-dione
• Empirical Formula (Hill Notation): C₂₂H₁₈ClN₃O₄
• CAS Number: 1259085-33-0
• Molecular Weight: 423.85
• MDL number: MFCD30533398
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: O=C1N2[C@@H](C3=CC4=C(C=C3C[C@]2(C(N(C)C1)=O)[H])OCO4)C5=CNC6=CC=C(Cl)C=C56
• InChI: 1S/C22H18ClN3O4/c1-25-9-20(27)26-17(22(25)28)4-11-5-18-19(30-10-29-18)7-13(11)21(26)15-8-24-16-3-2-12(23)6-14(15)16/h2-3,5-8,17,21,24H,4,9-10H2,1H3/t17-,21-/m0/s1
• InChI key: FSEZESVJDPKRDS-UWJYYQICSA-N

Description

Biochem/physiol Actions

Cell-permeable, selective PIP5K1α inhibitor that blocks its downstream PI3K/AKT phosphorylation and the production of PI(4,5)P2 from its PI(4)P precursor.



ISA-2011B is a cell-permeable, selective PIP5K1α inhibitor that blocks its downstream PI3K/AKT phosphorylation and the production of PI(4,5)P2 from its PI(4)P precursor. ISA-2011B effectively inhibits propagation of both measles and nipah viruses in cell culture (40 - 50 µM) with minimal toxicity, suppresses inflammation, cancer growth and invasion in multiple models.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable