I6160
ITK (352-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
EMT, LYK, MG C126257, MGC126258, PSCTK2
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
49-67 nmol/min·mg
mol wt
~53 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ITK(3702)
General description
ITK (IL2-inducible T-cell kinase) is a member of the Tec family of tyrosine kinases. ITK is expressed in T-cells.
Biochem/physiol Actions
ITK (IL2-inducible T-cell kinase) is important for T-cell activation through the T-cell antigen receptor. Absence of ITK in T cells causes impairment in TCR (T cell receptor)-mediated actin polymerization, cell polarization and signaling events associated with cytoskeletal reorganization.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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