G9513

γ-Globulins from goat

≥99% (agarose gel electrophoresis)

• CAS Number: 9007-83-4
• EC Number: 232-706-1
• MDL number: MFCD00164084
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: goat
• Quality Level: 200
• Assay: ≥99% (agarose gel electrophoresis)
• form: powder
• impurities: 2-4% NaCl
• storage temp.: −20°C

Description

General description

γ-Globulins are glycoproteins that are antibodies produced by plasma cells. They are immunoglobulins and exist in five classes, namely: IgG, IgM, IgA, IgD, and IgE. Immunoglobulins are heterogeneous molecules that constitute 20% of the plasma proteins. They are made up of four polypeptide chains (two light chains and two heavy chains) linked together by disulfide bonds. The antigen-binding site is present at the nitrogen terminal.

Biochem/physiol Actions

Immunoglobulins are generated in response to antigens, and they serve as key regulators of the immune system. They protect our bodies against bacteria, viruses, and fungi. Immunoglobulins are involved in the activation of the complement system, opsonization of microbes for phagocytosis, neutralization of toxins and viruses, and inhibition of the attachment of microbes to mucosal surfaces. Immunodeficiency can lead to recurrent infectious diseases.

Preparation Note

Prepared from Cohn Fraction II, III

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves