D0256
Dulcitol
≥99% (GC)
Synonym(s):
Dulcite, Galactitol
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721903
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
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Quality Level
Assay
≥99% (GC)
form
crystals
sweetness
<0.6 × sucrose
color
white
solubility
water: 50 mg/mL, clear, colorless
SMILES string
OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)CO
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6-
InChI key
FBPFZTCFMRRESA-GUCUJZIJSA-N
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Application
Dulcitol (Galactitol), a sugar alcohol derived through reduction of galactose, is important in studies related to cataract formation, hepatosplenomegaly and mental retardation. It is used as a substrate to identify, differentiate and characterize galactitol dehydrogenase(s). Galactitol may be used as a reference compound in analytical procedures developed to analyze sugar alcohols in plants and food.
Biochem/physiol Actions
A sugar alcohol and slightly sweet tastant for human taste cells.
Other Notes
To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Richard F G Fröhlich et al.
Bioorganic & medicinal chemistry letters, 21(22), 6872-6875 (2011-10-07)
N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol, a strong competitive inhibitor of β-galactosidase, enhances residual β-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant β-gal as well as aberrant GM1 gangliosides by live cell imaging.
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The Journal of pediatrics, 154(5), 721-726 (2009-02-03)
To determine the long-term outcome of dietary intervention in siblings from 14 Irish families with classical galactosemia (McKusick 230400), an autosomal recessive disorder of carbohydrate metabolism and galactose-1-phosphate uridyltransferase (GALT) deficiency. Outcomes in siblings on dietary galactose restriction were studied
C Jakobs et al.
Pediatric research, 18(8), 714-718 (1984-08-01)
A stable isotope dilution assay for galactitol in amniotic fluid has been developed using selected ion monitoring chemical ionization gas chromatography-mass spectrometry of the hexaacetate derivative. [1,1-2H2]Galactitol was synthesized for use as the internal standard. Galactitol is a component of
Peter F Kador et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 25(4), 299-308 (2009-05-20)
The two most widely investigated animal models for diabetic retinopathy (DR) are the rat and dog. In dogs, aldose reductase (AR) is present only in retinal capillary pericytes and their destruction has been linked to polyol accumulation and resulting apoptosis.
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