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38490

Supelco

5,5-Dimethyl-1,3-cyclohexanedione

for HPLC derivatization, for the determination of aldehyde formaldehyde, ≥99.0%

Synonym(s):

Dimedone, Methone

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About This Item

Linear Formula:
(CH3)2C6H6(=O)2
CAS Number:
Molecular Weight:
140.18
Beilstein:
471489
EC Number:
MDL number:
UNSPSC Code:
12164500
PubChem Substance ID:
NACRES:
NA.21

grade

for HPLC derivatization

Quality Level

Assay

≥99.0% (GC)
≥99.0%

quality

for the determination of aldehyde formaldehyde

mp

146-148 °C (lit.)

application(s)

general analytical

SMILES string

CC1(C)CC(=O)CC(=O)C1

InChI

1S/C8H12O2/c1-8(2)4-6(9)3-7(10)5-8/h3-5H2,1-2H3

InChI key

BADXJIPKFRBFOT-UHFFFAOYSA-N

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General description

5,5-dimethyl-1,3-cyclohexanedione (Dimedone) is basically a highly sensitive and very specific reagent used for the determination of aldehydes. It is highly advantageous as it is environment friendly, give high yields and is a simple workup procedure.

Application

5,5-dimethyl-1,3-cyclohexanedione may be used in condensation reaction with aromatic aldehyde in ethylene glycol. It may be also be used in trace analysis of aldehydes by HPLC.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Condensation of aromatic aldehydes with 5, 5-dimethyl-1, 3-cyclohexanedione without catalyst.
Shujiang Tu
Synthetic Communications, 32 (19), 3063-3067 (2002)
Solid-State Condensation Reactions Between Aldehydes and 5, 5-Dimethyl-1, 3-cyclohexanedione by Grinding at Room Temperature.
Tong-shou J
Synthetic Communications, 35 (17), 2339-2345 (2005)
Jesse C Patterson et al.
Cell systems, 8(2), 163-167 (2019-02-25)
Although elevated levels of reactive oxygen species (ROS) have been observed in cancer cells and cancer cells aberrantly proliferate, it is not known whether the level of reactive oxygen species and the accumulation of oxidative damage to macromolecules vary across
Trace analysis of aldehydes by reversed-phase high-performance liquid chromatography and precolumn fluorigenic labeling with 5, 5-dimethyl-1, 3-cyclohexanedione.
Kenneth M
Journal of Chromatography A, 256, 243-252 (1983)
Ryan D Michalek et al.
Journal of immunology (Baltimore, Md. : 1950), 179(10), 6456-6467 (2007-11-06)
Reactive oxygen intermediates (ROI) generated in response to receptor stimulation play an important role in mediating cellular responses. We have examined the importance of reversible cysteine sulfenic acid formation in naive CD8(+) T cell activation and proliferation. We observed that

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