567540

Sodium Orthovanadate

A broad spectrum potent inhibitor of protein tyrosine phosphatases.

• Synonym(s): Sodium Orthovanadate, PTP Inhibitor X
• Empirical Formula (Hill Notation): Na₃O₄V
• CAS Number: 13721-39-6
• Molecular Weight: 183.91
• MDL number: MFCD00003511
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: water: 10 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/3Na.4O.V/q3*+1;;3*-1;
• InChI key: IHIXIJGXTJIKRB-UHFFFAOYSA-N

Description

General description

A broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na⁺,K⁺-ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Also inhibits the ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK₂) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.

A broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na⁺/K⁺ ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Most recently shown to inhibit ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK₂) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Na⁺,K⁺-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Huyer, G., et al. 1997. J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun.216, 589.
Levchuck, S.G., et al. 1994. Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989. Biochem. J.262, 83.
Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J.181, 247.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332,H315,H319
• Precautionary Statements: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable