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Key Documents

05-486

Sigma-Aldrich

Anti-FADD Antibody, clone 1F7

clone 1F7, Upstate®, from mouse

Synonym(s):

Anti-GIG3, Anti-IMD90, Anti-MORT1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

1F7, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... FADD(8772)
mouse ... Fadd(14082)

Specificity

FADD

Immunogen

GST-tagged full-length fusion protein corresponding to human FADD

Application

Anti-FADD Antibody, clone 1F7 detects level of FADD & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Quality

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

Target description

28kDa

Linkage

Replaces: 04-1113

Physical form

Format: Purified
PBS, pH 7.2 and 50% glycerol
Protein A chromatography

Storage and Stability

2 years at -20°C

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9.
K Kim et al.
Cell death and differentiation, 11(5), 583-587 (2004-01-31)
Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance.
Thompson, SJ; Ashley, MD; Stohr, S; Schindler, C; Li, M; McCarthy-Culpepper, KA; Pearson et al.
International Journal of Physiology, Pathophysiology and Pharmacology null
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling
McDonald, E. R., 3rd, et al
The Journal of Biological Chemistry, 276, 14939-14945 (2001)
Katerina Vlantis et al.
Immunity, 44(3), 553-567 (2016-03-18)
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired antimicrobial factor
Eun-Young Ahn et al.
International journal of cancer, 100(4), 445-451 (2002-07-13)
Human cholangiocarcinoma is a malignancy with no effective therapy and a poor prognosis. Previously, we demonstrated that cultured human cholangiocarcinoma cell lines heterogeneously express Fas on their surface, resulting in 2 subpopulations, Fas-high and Fas-low cells. Fas-low cells are resistant

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