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850398P

Avanti

22:1 (Cis) PC

1,2-dierucoyl-sn-glycero-3-phosphocholine, powder

Synonym(s):

1,2-di-(13Z-docosenoyl)-sn-glycero-3-phosphocholine; PC(22:1(13Z)/22:1(13Z)); DEPC

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About This Item

Empirical Formula (Hill Notation):
C52H100NO8P
CAS Number:
Molecular Weight:
898.33
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (850398P-25mg)

manufacturer/tradename

Avanti Research - A Croda Brand 850398P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)=O

InChI

1S/C52H100NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h20-23,50H,6-19,24-49H2,1-5H3/b22-20+,23-21+/t50-/m1/s1

InChI key

SDEURMLKLAEUAY-QVOKQPLLSA-N

General description

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

22:1 (Cis) PC has been used as in the preparation of model membrane mimicking T-cell (LM3). It is suitable for use to study about lipid dynamics and also to investigate the effect of cholesterol on it.

Biochem/physiol Actions

22:1 (Cis) PC/1,2-dierucoyl-sn-glycero-3-phosphocholine (DEPC) is a longer lipid. It is 7 Å thicker, when compared to 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

Packaging

5 mL Clear Glass Sealed Ampule (850398P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics
Tristram NS, et al.
Journal of Molecular Biology, 402(1), 139-153 (2010)
How phospholipid-cholesterol interactions modulate lipid lateral diffusion, as revealed by fluorescence correlation spectroscopy
Kahya N and Schwille P
Journal of Fluorescence, 16(5), 671-678 (2006)
Dependence of M13 major coat protein oligomerization and lateral segregation on bilayer composition
Fernandes F, et al.
Biophysical Journal, 85(4), 2430-2441 (2003)
Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths
Weber ME, et al.
Journal of the American Chemical Society, 127(2), 636-642 (2005)
Gareth R Tibbs et al.
The Journal of pharmacology and experimental therapeutics, 345(3), 363-373 (2013-04-04)
Chronic pain after peripheral nerve injury is associated with afferent hyperexcitability and upregulation of hyperpolarization-activated, cyclic nucleotide-regulated (HCN)-mediated IH pacemaker currents in sensory neurons. HCN channels thus constitute an attractive target for treating chronic pain. HCN channels are ubiquitously expressed;

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