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Key Documents

935468

Sigma-Aldrich

Aldehyde functionalized hyaluronic acid

Degree of functionalization ~40%

Synonym(s):

HA aldehyde, HA-A, Hyaluronic acid A. Oxidized Hyaluronic acid

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About This Item

Linear Formula:
(C14H20NNaO11)n(C14H18NNaO11)m
UNSPSC Code:
12352201
NACRES:
NA.28

Quality Level

form

powder or chunks ( or fibers)

color

white to off-white

storage temp.

−20°C

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General description

Hyaluronic acid (HA) is an important component of the natural extracellular matrix which plays a vital role in various cellular and tissue functions. It represents some unique properties such as excellent gel-forming properties and chemical modification ability through hydroxyl and carboxyl groups that make them useful for tissue engineering applications. Aldehyde functionalized hyaluronic acid, or partially oxidized hyaluronic acid, contains two aldehyde groups in the repeating unit of HA. The dialdehyde groups are capable of reductive coupling with primary amines, providing a platform for a wide range of chemical modifications for a variety of applications.

Application

HA is increasingly used for a many biomedical applications because it promotes cell migration, angiogenesis, cell viability, and proliferation. Aldehyde functionalized HA can be used to develop hydrogels for tissue engineering, regenerative medicing, bioprinting, and drug delivery applications.

Features and Benefits

  • Coupling capabilities with primary amines
  • Biocompatible functionalized natural polymer
  • Promotes a variety of cellular and tissue functions

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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General dialdehyde click chemistry for amine bioconjugation
Elahipanah S, et al.
Bioconjugate Chemistry, 28, 1422-1433 (2017)
Hyaluronic Acid and Controlled Release: A Review
Ilker S. Baye, et al.
Molecules (Basel), 25, 2649-2649 (2020)
Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery
Trombino S, et al.
Pharmaceutics, 11, 407-407 (2019)
Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine
Franca C G, et al.
Polysaccharides, 2, 477-496 (2021)
Modified hyaluronic acid-based materials for biomedical applications
Tiwari S, et al.
International Journal of Biological Macromolecules, 121, 556-571 (2019)

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