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725986

Sigma-Aldrich

Trimethylsilanol

≥97.5% (GC)

Synonym(s):

TMS, TMSiOH, Hydroxytrimethylsilane

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About This Item

Linear Formula:
(CH3)3SiOH
CAS Number:
1066-40-6
Molecular Weight:
90.20
Beilstein:
1361356
EC Number:
213-914-1
MDL number:
MFCD02751657
UNSPSC Code:
12352103
PubChem Substance ID:
329764205
NACRES:
NA.22

Quality Level

100

Assay

≥97.5% (GC)

form

liquid

SMILES string

C[Si](C)(C)O

InChI

1S/C3H10OSi/c1-5(2,3)4/h4H,1-3H3

InChI key

AAPLIUHOKVUFCC-UHFFFAOYSA-N

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Application

Trimethylsilanol (TMS) can be used to prepare tris(trimethylsiloxy) aluminum (I) by reacting with triethylaluminum.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H332,H412

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

44.6 °F - closed cup

Flash Point(C)

7 °C - closed cup

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During the past years, there has been an increasing focus on the presence of silicone oil as a contaminant in pharmaceutical formulations kept in prefilled syringes (PFSs). As the PFSs are coated on the inner wall with silicone oil (polydimethylsiloxane)
Reactions of Aldehyde Caused by Tris (trimethylsiloxy) aluminum.
Saegusa T, et al.
Bulletin of the Chemical Society of Japan, 40(8), 1960-1964 (1967)
Xiao-Meng Chong et al.
Drug development and industrial pharmacy, 45(1), 159-167 (2018-09-21)
Establish an effective experimental strategy to determine the compatibility of rubber closures for drugs. Various types of rubber closures with different compositions are available for drug packaging. Many additives of rubber closures can be released from rubber closures and may
D M Hui et al.
Clinica chimica acta; international journal of clinical chemistry, 302(1-2), 171-188 (2000-11-14)
We developed a new assay method for fluoride anion (F(-)) a specific metabolite of sarin. Trimethyifluorosilane (TMFS) was derivatized from F(-) with trimethylsilanol, and TMFS was detected with a GC-flame ionization detector (FID) and capillary column system. The linear range
A Isquith et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(3), 263-266 (1988-03-01)
Six organosilicon compounds which had been found to have clastogenic activity in an in vitro battery of genotoxicity assays were evaluated in rat bone marrow cytogenetic assays for assessing clastogenicity in an in vivo system. None of the six compounds
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