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47782

Supelco

D-α-Tocopherol succinate

analytical standard

Synonym(s):

Vitamin E succinate

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About This Item

Empirical Formula (Hill Notation):
C33H54O5
CAS Number:
Molecular Weight:
530.78
Beilstein:
4038233
EC Number:
MDL number:
UNSPSC Code:
12164500
PubChem Substance ID:

grade

analytical standard

CofA

current certificate can be downloaded

feature

standard type fat soluble vitamin

packaging

ampule of 100 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

format

neat

storage temp.

2-8°C

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1

InChI

1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1

InChI key

IELOKBJPULMYRW-NJQVLOCASA-N

General description

D-α-Tocopherol succinate is a potent antioxidant tocopherol with antitumor activity and inhibits colon cancer liver metastases.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Vitamin E succinate inhibits colon cancer liver metastases
Barnett TK, et al.
The Journal of Surgical Research, 106(2), 292-298 (2002)
Vitamin E succinate promotes breast cancer tumor dormancy
Malafa PM, et al.
The Journal of Surgical Research, 93(1), 163-170 (2000)
Dasheng Wang et al.
Journal of medicinal chemistry, 52(18), 5642-5648 (2009-08-28)
This study is aimed at the pharmacological exploitation of alpha-tocopheryl succinate (1) to develop potent antiadhesion agents. Considering the structural cooperativity between the phytyl chain and the carboxylic terminus in determining the antiadhesion activity, our structural optimization led to compound
Yanyun Xu et al.
International journal of pharmaceutics, 495(2), 792-797 (2015-09-28)
Our recent publication showed that VES-dFdC nanocapsules in pure water could be obtained via the self-assembling of VES-dFdC prodrug synthesized by coupling gemcitabine (dFdC) with vitamin E succinate (VES). To prepare the intravenous injection nanoformulation, we present here a novel
Pengfei Xu et al.
Biomaterials, 35(26), 7574-7587 (2014-06-06)
Metastasis is one of the major obstacles for the successful therapy of breast cancer. Although increased candidate drugs targeting cancer metastasis are tested, their clinical translation is limited by either serve toxicity or low efficacy. In present work, a nano-drug

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