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M7319

Sigma-Aldrich

ML 10302

≥98%, solid

Synonym(s):

2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate

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About This Item

Empirical Formula (Hill Notation):
C15H21ClN2O3
CAS Number:
148868-55-7
Molecular Weight:
312.79
MDL number:
MFCD00931669
UNSPSC Code:
12352202
PubChem Substance ID:
24724541
NACRES:
NA.77

Quality Level

100

Assay

≥98%

form

solid

color

white to off-white

solubility

DMSO: >20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

COc1cc(N)c(Cl)cc1C(=O)OCCN2CCCCC2

InChI

1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3

InChI key

RVFIAQAAZUEPPE-UHFFFAOYSA-N

Gene Information

rat ... Htr3a(79246) , Htr4(25324)

Biochem/physiol Actions

Potent, selective 5-HT4 serotonin receptor agonist

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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F De Ponti et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 13(6), 543-553 (2002-03-21)
5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the
Jean-Louis Soulier et al.
Journal of medicinal chemistry, 48(20), 6220-6228 (2005-09-30)
Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception and the synthesis of bivalent molecules able to influence the dimerization
D Yang et al.
Journal of medicinal chemistry, 40(4), 608-621 (1997-02-14)
A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum and the rat esophagus muscle. Monosubstitution

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