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HPA052294

Sigma-Aldrich

Anti-KMT5C antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-MGC2705, Anti-SUV420H2, Anti-KMT5C, Anti-suppressor of variegation 4-20 homolog 2 (Drosophila)

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500

immunogen sequence

EGFFGEKNEHCECHTCERKGEGAFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSG

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

General description

Lysine methyltransferase 5C (KMT5C) is a H4K20 dimethylase. The gene is located on human chromosome 19q13.42.

Immunogen

lysine methyltransferase 5C recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-KMT5C antibody produced in rabbit has been used in immunofluorescence imaging and analysis.

Biochem/physiol Actions

Lysine methyltransferase 5C (KMT5C) plays an important role in maintaining genomic integrity. It methylates lysine 20 of histone H4 (H4K20), which is important in transcriptional regulation. The protein functions as a regulator of epithelial-mesenchymal transition (EMT). It preserves the integrity of osteoblast differentiation. The protein is strongly linked to pericentric heterochromatin. Deficiency of KMT5C is associated with increased telomere elongation, which is related to tumors.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST82686

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer
Viotti M, et al.
The Journal of Cell Biology, 217(2), 763-777 (2018)
The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours
Souza PP, et al.
BMC Cell Biology, 10(1), 41-41 (2009)
Histone H4 methyltransferase Suv420h2 maintains fidelity of osteoblast differentiation
Khani F, et al.
Journal of Cellular Biochemistry, 118(5), 1262-1272 (2017)
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer
Liu L, et al.
Oncotarget, 6(4), 2466-2466 (2015)
NF-κB-dependent and-independent epigenetic modulation using the novel anti-cancer agent DMAPT
Nakshatri H, et al.
Cell Death & Disease, 6(1), e1608-e1608 (2015)

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