Skip to Content
Merck
All Photos(3)

Key Documents

208213

Sigma-Aldrich

Polyphosphoric acid

greener alternative

reagent grade, 115% H3PO4 basis

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
Hn+2PnO3n+1
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352106
eCl@ss:
38070203
NACRES:
NA.21

grade

reagent grade

Quality Level

Assay

115% H3PO4 basis

form

viscous liquid

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

bp

300 °C (lit.)

density

2.06 g/mL at 25 °C

greener alternative category

InChI

1S/O5P2.H3O4P/c1-2-7-4-3-6(1)5-7;1-5(2,3)4/h;(H3,1,2,3,4)

InChI key

FVYIVXLIMHNYTD-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Polyphosphoric acid (PPA) is widely employed as acylation and alkylation reagent in various reactions. It is a strong mineral acid with excellent dehydrating properties.

Application

Polyphosphoric acid may be used in the synthesis of aromatic sulfones, N-substituted amides and 4-aminobenzophenones. It may also be used in dehydration, Fischer-Indole Synthesis, Beckmann Rearrangement and Schmidt Rearrangement reactions. It can be used as a catalyst in the synthesis of various aromatic ketones.
PPA may be used as a catalyst during the synthesis of dimethyl carbonate (DMC) from urea and methanol. It also acts as an absorbent for the ammonia generated in the process. PPA may be used to prepare silica-supported polyphosphoric acid (PPA-SiO2), an easy to handle, reusable heterogenous catalyst.

Other Notes

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

906. Synthetic uses of polyphosphoric acid.
Denton DA and Suschitzky H.
Journal of the Chemical Society, 4741-4743 (1963)
Silica-supported polyphosphoric acid (PPA-SiO2): An efficient and reusable heterogeneous catalyst for ecofriendly organic synthesis.
Vekariya RH, et al.
Synthetic Communications, 46(3), 197-219 (2016)
Synthesis of dimethyl carbonate from urea and methanol using polyphosphoric acid as catalyst.
Sun J, et al.
J. Mol. Catal. A: Chem., 239(1), 82-86 (2005)
M K Gabriel et al.
Analytical biochemistry, 149(2), 339-343 (1985-09-01)
An ion-pair, reverse-phase, high-performance liquid chromatography method of assay was developed and used in a series of rate studies carried out with the enzyme chicken liver NAD+ kinase (ATP:NAD+ 2'-phosphotransferase, EC 2.7.1.23). Complete separation of all products and reactants was
Kenji Maekawa et al.
Journal of biomedical materials research. Part A, 82(1), 195-200 (2007-02-03)
The aim of this study was to evaluate the effect of treating titanium (Ti) with polyphosphoric acid on the attachment and proliferation of human bone marrow derived mesenchymal stem cells (hBMSCs). Cleaned Ti disks were immersed into three different concentrations

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service