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O1378

Supelco

Oxycodone hydrochloride

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C18H21NO4 · HCl
CAS Number:
Molecular Weight:
351.82
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.[H][C@@]12Oc3c(OC)ccc4C[C@H]5N(C)CC[C@@]1(c34)[C@@]5(O)CCC2=O

InChI

1S/C18H21NO4.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;/h3-4,13,16,21H,5-9H2,1-2H3;1H/t13-,16+,17+,18-;/m1./s1

InChI key

MUZQPDBAOYKNLO-RKXJKUSZSA-N

Gene Information

human ... OPRM1(4988)

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General description

Oxycodone hydrochloride is an analgesic drug, which is generally used in cancer treatment since it can reduce the pain induced during the treatment.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

μ and κ opioid receptor agonist.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation.
Jonathan R McDaniel et al.
Angewandte Chemie (International ed. in English), 52(6), 1683-1687 (2013-01-03)
Clinical observations on safety and efficacy of OxyContin? administered by rectal route in treating cancer related pain
Li G-C, et al.
Asian Pacific Journal of Cancer Prevention, 12, 2477-2478 (2011)
Rachel E Martin et al.
eNeuro, 8(4) (2021-07-28)
Opioid drugs are increasingly being prescribed to pregnant women. Such compounds can also bind and activate opioid receptors in the fetal brain, which could lead to long-term brain and behavioral disruptions. We hypothesized that maternal treatment with oxycodone (OXY), the
Brady K Atwood et al.
Nature neuroscience, 17(4), 540-548 (2014-02-25)
As prescription opioid analgesic abuse rates rise, so does the need to understand the long-term effects of opioid exposure on brain function. The dorsal striatum is an important site for drug-induced neuronal plasticity. We found that exogenously applied and endogenously
Marco Pravetoni et al.
Journal of medicinal chemistry, 56(3), 915-923 (2012-12-20)
Prescription opioids abuse and associated deaths are an emerging concern in the USA. Vaccination against prescription opioids may provide an alternative to pharmacotherapy. An oxycodone hapten containing a tetraglycine linker at the C6 position (6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin

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