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8.22339
Phosphoryl chloride
for synthesis
Synonym(s):
Phosphoryl chloride, Phosphorus oxide trichloride, Phosphorus oxychloride
About This Item
Recommended Products
grade
for synthesis
Quality Level
vapor pressure
36 hPa ( 20 °C)
Assay
≥99.0% (argenometric)
form
liquid
potency
36 mg/kg LD50, oral (Rat)
dilution
(for synthesis)
pH
1.0 (25 °C, 5 g/L in H2O)
bp
105.3 °C/1013 hPa
mp
1-2 °C
density
1.68 g/cm3 at 20 °C (DIN 51757)
storage temp.
2-30°C
SMILES string
[P](=O)(Cl)(Cl)Cl
InChI
1S/Cl3OP/c1-5(2,3)4
InChI key
XHXFXVLFKHQFAL-UHFFFAOYSA-N
General description
Application
- A phosphorylating agent for the selective phosphorylation of alcohols, amines, and thiols.[1]
- A dehydrating agent for alcohols, amides, and cyanohydrins.[1][2]
- A reagent to synthesize Vilsmeier reagent for Vilsmeier-Haack formylation reactions.[1]
- A chlorinating agent for the chlorination of heterocyclic compounds.[1]
- A reagent to prepare dihydroisoquinolines and isoquinolines by cyclization of N-β-phenylethyl amides via Bischler-Napieralski reaction.[1]
Analysis Note
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - STOT RE 1 Inhalation
Target Organs
Respiratory Tract
Supplementary Hazards
Storage Class Code
6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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