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Key Documents

8.20877

Sigma-Aldrich

(-)-Nicotine

for synthesis

Synonym(s):

(-)-Nicotine, 3-(1-Methyl-2-pyrrolidinyl)pyridine, (S)-(-)-Nicotine

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About This Item

Empirical Formula (Hill Notation):
C10H14N2
CAS Number:
Molecular Weight:
162.23
MDL number:
UNSPSC Code:
12352005
EC Index Number:
200-193-3
NACRES:
NA.22
Pricing and availability is not currently available.

vapor pressure

0.06 hPa ( 20 °C)

Quality Level

Assay

≥99.0% (GC)

form

liquid

autoignition temp.

240 °C

potency

50 mg/kg LD50, oral (Rat)
50 mg/kg LD50, skin (Rabbit)

expl. lim.

0.7-4 % (v/v)

pH

10.2 (20 °C, 8.1 g/L in H2O)

bp

248.8 °C/1013 hPa

mp

-79 °C

transition temp

flash point 111 °C

density

1.01 g/cm3 at 20 °C

storage temp.

2-30°C

SMILES string

N1([C@@H](CCC1)c2cnccc2)C

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1

InChI key

SNICXCGAKADSCV-JTQLQIEISA-N

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.009 - 1.012
Enantiomeric purity: ≥ 99.0 % (a/a)
Identity (IR): passes test

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

213.8 °F - closed cup

Flash Point(C)

101 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. This is pure nicotine solution, right? This is not nicotine that has been dissolved in a solvent.

    1 answer
    1. Yes, this product is a neat or pure form of Nicotine. Based on a density of 1.02 g/ml and a molecular weight of 162.2 g/mole, this neat liquid has a calculated molar concentration of 6.3 M.

      Helpful?

  4. What is the concentration in the 25ml bottle preferably in mg/ml

    1 answer
    1. This product is a neat liquid with a minimum purity of 99%. The density is 1.01 g/mL and the molecular weight is 162.23. The calculated concentration of this product is approximately 6.2 M. This value will change slightly when considering the lot specific purity. This product is not tested for moisture content.

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