498270

1-Chloro-N,N,2-trimethyl-1-propenylamine

96%

• Synonym(s): Ghosez′s reagent
• Linear Formula: (CH₃)₂C=C(Cl)N(CH₃)₂
• CAS Number: 26189-59-3
• Molecular Weight: 133.62
• MDL number: MFCD00800562
• UNSPSC Code: 12352302
• PubChem Substance ID: 24873186
• NACRES: NA.22

Properties

• Assay: 96%
• refractive index: n20/D 1.453 (lit.)
• bp: 129-130 °C (lit.)
• density: 1.01 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CN(C)\C(Cl)=C(\C)C
• InChI: 1S/C6H12ClN/c1-5(2)6(7)8(3)4/h1-4H3
• InChI key: GQIRIWDEZSKOCN-UHFFFAOYSA-N

Description

Application

1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine.

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226,H314
• Precautionary Statements: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Flam. Liq. 3 - Skin Corr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 80.0 °F - closed cup
• Flash Point(C): 26.67 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves