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M8816

Sigma-Aldrich

Microsomes from Liver, Pooled

from Monkey(Cynomolgus spp.), male

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About This Item

UNSPSC Code:
12161501
NACRES:
NB.35

Pricing and availability is not currently available.

biological source

Monkey (Cynomolgus spp.)

form

liquid

specific activity

≥5000 units/mg protein

packaging

vial of ~10 mg

shipped in

dry ice

storage temp.

−70°C

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Application

Microsomes from Liver, Pooled has been used to measure the in vitro stabilities of the prodrugs.[1] It has also been used in microsomal incubation to generate BTX-3 metabolites to serve as references for liquid chromatography with tandem mass spectrometry (LC-MS/MS) analyses of urine.[2]

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomal cytochrome P450 proteins can catalyze the transfer of a single oxygen atom to endogenous and exogenous compounds, like steroids and phenobarbital, meant for excretion and detoxification.[3]

Unit Definition

One unit will produce 1.0 picomole of 6 beta-hydroxytestosterone per minute at pH 7.4 at 37 deg C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Biochemistry and cell biology
    The Cytokine Handbook (2016)
    Ann Abraham et al.
    Toxicon : official journal of the International Society on Toxinology, 52(2), 237-245 (2008-06-28)
    Urine specimens from patients diagnosed with neurotoxic shellfish poisoning (NSP) were examined for biomarkers of brevetoxin intoxication. Brevetoxins were concentrated from urine by using solid-phase extraction (SPE), and analyzed by enzyme-linked immunosorbent assay (ELISA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS).
    Kumar Sachin Singh et al.
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    Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration1. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bacteria, mycobacteria and apicomplexans2,3. Its

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