I0879

Inosine 5′-triphosphate trisodium salt

≥95%

• Synonym(s): ITP
• Empirical Formula (Hill Notation): C₁₀H₁₂Na₃N₄O₁₄P₃
• CAS Number: 35908-31-7
• Molecular Weight: 574.11
• MDL number: MFCD00084678
• UNSPSC Code: 41106305
• PubChem Substance ID: 24895910
• NACRES: NA.51

Properties

• Quality Level: 200
• Assay: ≥95%
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
• InChI: 1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
• InChI key: RIERCUPIZLBNFQ-UHFFFAOYSA-N
• Gene Information: human ... HRAS(3265)

Description

Application

Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.

Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.[1]

Biochem/physiol Actions

Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP.[2] Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription.[3] ITP can also replace GTP in the activation of G-protein.[2]

Preparation Note

Prepared from Bacterial ATP

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable