The cannister is not considered the primary packaging; instead, it serves as an overpack, providing protective casing for the product.
1. To open the canister, a can opener can be used, unless the item features a flip-top, in which case the tab can be flipped up and pulled to pry open the top, similar to a soup can.
2. The primary packaging for this product consists of a 2.5L amber glass bottle with a red polypropylene cap, HDPE, and PTFE liner.
319988
Chloroform
Chloroform
1 of 1 reviewers received a sample product or took part in a promotion
contains ethanol as stabilizer, ACS reagent, ≥99.8%
Synonym(s):
Methylidyne trichloride, Trichloromethane
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About This Item
Empirical Formula (Hill Notation):
CHCl3
CAS Number:
Molecular Weight:
119.38
Beilstein:
1731042
MDL number:
UNSPSC Code:
12191502
PubChem Substance ID:
NACRES:
NA.21
grade:
ACS reagent
Assay:
≥99.8%
bp:
60.5-61.5 °C (lit.)
vapor pressure:
160 mmHg ( 20 °C)
Pricing and availability is not currently available.
Recommended Products
grade
ACS reagent
Quality Level
vapor density
4.1 (vs air)
vapor pressure
160 mmHg ( 20 °C)
Assay
≥99.8%
form
liquid
contains
ethanol as stabilizer
impurities
Acetone and aldehyde, passes test
Acid and chloride, passes test
Free chlorine (Cl), passes test
H2SO4, passes test
evapn. residue
≤0.001%
color
APHA: ≤10
refractive index
n20/D 1.445 (lit.)
bp
60.5-61.5 °C (lit.)
mp
−63 °C (lit.)
density
1.48 g/mL at 25 °C
1.492 g/mL at 25 °C (lit.)
cation traces
Pb: ≤0.05 ppm
storage temp.
room temp
SMILES string
ClC(Cl)Cl
InChI
1S/CHCl3/c2-1(3)4/h1H
InChI key
HEDRZPFGACZZDS-UHFFFAOYSA-N
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General description
Chloroform, a halogenated hydrocarbon, is widely used as a solvent and extractant in various manufacturing and laboratory procedures. It can be produced by the chlorination of methane or lower-chlorinated methanes. Additionally, it is employed in the production of dichlorocarbenes, α-trichloromethyl carbinols, and trichlorolithiocarbenoids.
Application
Chloroform can be used as a solvent in the:
- Enzyme-catalyzed ring-opening polymerization of ω-pentadecalactone to prepare polyesters.
- Pd-catalyzed cross-coupling reaction of acid chlorides with arylboronic acids to synthesize diaryl Ketones.
- Enantio- and diastereoselective nitro-Mannich reaction of α-aryl nitromethanes with amido sulfones to synthesize β-nitroamines.
- Diels-Alder reaction to synthesize spiro-fused dihydropyans. The hydrogen bond (CH-O) formed between chloroform and carbonyl oxygen makes the carbonyl group a stronger heterodienophile, resulting in an increased reaction rate.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
Storage Class Code
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Flash Point(F)
does not flash
Flash Point(C)
does not flash
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How do we open the thin metal container in which the chloroform (Item Number: 319988-2.5L) was shipped? Also, what is the primary packaging for this product?
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What are the options for drying solvents?
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Sigma-Aldrich offers a full range of high-purity solvents with extremely low water levels specifically manufactured for moisture sensitive Organic and Biotech applications. Sigma-Aldrich also carries various drying agents such as molecular sieves, which are typically compatible with organic solvents.
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Who do I contact about larger solvent volume needs?
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Email us at [email protected] or visit Sigma-Aldrich Fine Chemicals for development and manufacturing-scale inquiries: [email protected]
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Can you recommend a Solvent Extractor for organics from aqueous solution?
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Solvent extractors are often used for the quantitative extraction of organics from aqueous solutions and separations in immunoassays. The MIXXOR system has been applied successfully in many laboratory solvent extraction operations and is ideal for the rapid screening of alternative solvents for specific extraction problems.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What apparatus do you recommend for HPLC solvent filtration?
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The Sigma-Aldrich Vacuum Filtration Assembly gives you all the components you need including: funnel top, fritted glass funnel support, filtration flask, aluminum clamp, and silicone stopper. The Acrodisc Syringe Filters offer high quality filtration for analytical samples, certified for HPLC to ensure low extractable and available in a broad range of membranes to meet sample compatibility requirements.
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