23182
(+)-1-(9-Fluorenyl)ethyl chloroformate solution
≥18 mM in acetone, for chiral derivatization, LiChropur™
Synonym(s):
(+)-FLEC solution
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About This Item
Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
Molecular Weight:
272.73
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
grade
for chiral derivatization
Quality Level
product line
ChiraSelect™
optical purity
enantiomeric ratio: ≥99.0:1.0 (HPLC)
quality
LiChropur™
concentration
≥18 mM in acetone
technique(s)
HPLC: suitable
refractive index
n20/D 1.359
storage temp.
2-8°C
InChI
1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3
InChI key
SFRVOKMRHPQYGE-UHFFFAOYSA-N
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General description
(+)-1-(9-Fluorenyl)ethyl chloroformate [(+)-FLEC] is a chiral derivatizing reagent. It helps in separating enantiomers of α-amino acids, as well as helps in determining its optical purity using HPLC method.
Application
(+)-FLEC may be used in enantioselective analysis of glufosinate using reversed-phase high-performance liquid chromatography system coupled with a fluorescence detection system.
Physical form
solution, 5 mg in 1 mL acetone
Other Notes
Chiral derivatizing agent for primary and secondary amino acids and amines. The derivatives are separated by reversed-phase LC with fluorescence detection for determining the enantiomeric purity
Legal Information
ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
Target Organs
Central nervous system
Supplementary Hazards
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
1.4 °F
Flash Point(C)
-17 °C
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Separation of enantiomers of a-hydroxy acids by reversed-phase liquid chromatography after derivatization with 1-(9-fluorenyl) ethyl chloroformate.
Fransson, Bengt, and Ulf Ragnarsson.
Journal of Chromatography A, 827, 31-36 (1998)
Yasushi Hori et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 776(2), 191-198 (2002-07-26)
We have developed a new analytical method to quantify the DL-homoalanine-4-yl(methyl)phosphinate (DL-GLUF) enantiomers in biological specimens using a reversed-phase high-performance liquid chromatography system with a fluorescence detection system. The derivatization of DL-GLUF enantiomers with (+)-1-(9-fluorenyl)ethyl chloroformate was carried out under
Separation of amino acid enantiomers and chiral amines using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate and reversed-phase liquid chromatography.
S Einarsson et al.
Analytical chemistry, 59(8), 1191-1195 (1987-04-15)
Identifying the carboxy terminal amino acid of a protein.
T H Akiyama et al.
Methods in molecular biology (Clifton, N.J.), 64, 235-242 (1997-01-01)
Zeineb Aturki et al.
Electrophoresis, 25(4-5), 607-614 (2004-02-26)
The indirect resolution of five beta-adrenoreceptor blocking agents (propranolol, oxprenolol, pindolol, metoprolol, and atenolol) using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC), and capillary electrochromatography (CEC) is reported. Three octadecylsilanized (ODS) silica gel-based stationary phases, differing in particle diameter and carbon
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