860468P
Avanti
N-C24:1-desoxymethylsphingosine
Avanti Research™ - A Croda Brand 860468P, powder
Synonym(s):
N-nervonoyl-1-desoxymethylsphingosine (m17:1/24:1)
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About This Item
Empirical Formula (Hill Notation):
C41H79NO2
CAS Number:
Molecular Weight:
618.07
UNSPSC Code:
12352211
NACRES:
NA.25
form
powder
packaging
pkg of 1 × 1 mg (860468P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860468P
lipid type
bioactive lipids
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Ceramides are generated by the acylation of the sphingoid bases, sphingosine.
Biochem/physiol Actions
Deoxydihydro ceramide (deoxyDHCer), nervonoyl (C24:1) is present in the mammals along with palmitoyl (C16) dihydroceramide. In general, deoxyDHCer modulates the cellular membrane properties and may contribute to its biological functionality.
Packaging
5 mL Amber Glass Screw Cap Vial (860468P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Sphingolipid biosynthesis in man and microbes
Harrison PJ, et al.
Natural Product Reports, 35(9), 921-954 (2018)
Biophysical properties of novel 1-deoxy-(dihydro) ceramides occurring in mammalian cells
Jimenez-Rojo N, et al.
Biophysical Journal, 107(12), 2850-2859 (2014)
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that
Sarah T Pruett et al.
Journal of lipid research, 49(8), 1621-1639 (2008-05-24)
"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now
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