F5396
Fenbendazole
≥98%
Synonym(s):
Methyl 5-(phenylthio)-2-benzimidazolecarbamate
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C15H13N3O2S
CAS Number:
Molecular Weight:
299.35
Beilstein:
759077
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
≥98%
SMILES string
COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1
InChI
1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
InChI key
HDDSHPAODJUKPD-UHFFFAOYSA-N
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General description
Fenbendazole also known as Methyl 5-(phenylthio)-2-benzimidazolecarbamate, is a benzimidazole anthelmintic and antiprotozoal agent.
Application
- Fenbendazole in Veterinary Medicine: Investigated for efficacy against coccidicidal fungi in avian species, demonstrating broad-spectrum antiparasitic potential. Additionally, its environmental impact and pharmacokinetics reveal insights for sustainable agricultural practices and disease vector control. (Lozano et al., 2024), (Hachgenei et al., 2024), (Durden et al., 2023).
- Food safety and allergen detection: Fenbendazole′s implications in food safety are explored through quantitative PCR methods for detecting allergenic species in foods, underscoring the importance of accurate detection techniques in food industry compliance and safety standards (Costa et al., 2023).
- Analysis of antibiotic and anthelmintic residues: The occurrence and exposure evaluation of Fenbendazole residues in cow milk in China is studied, emphasizing the need for rigorous monitoring of food products to ensure public health safety (Chang et al., 2023).
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
Target Organs
Liver,lymph node,Stomach,Nervous system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Niels C Kyvsgaard et al.
Veterinary parasitology, 181(2-4), 248-254 (2011-05-17)
Horses, mules and donkeys are indispensable farming and working animals in many developing countries, and their health status is important to the farmers. Strongyle parasites are ubiquitous in grazing horses world-wide and are known to constitute a threat to equine
C Chassaing et al.
Journal of medicinal chemistry, 51(5), 1111-1114 (2008-02-15)
Highly water-soluble prodrugs 1a- g of anthelmintic benzimidazole carbamates 2a- g were synthesized. These prodrugs combine high aqueous solubility and stability with high lability in the presence of alkaline phosphatases. The veterinary utility of 1a was shown by a pharmacodynamic
Nilambra Dogra et al.
The Journal of biological chemistry, 287(36), 30625-30640 (2012-06-30)
In recent years, there has been a great deal of interest in proteasome inhibitors as a novel class of anticancer drugs. We report that fenbendazole (FZ) (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate) exhibits a potent growth-inhibitory activity against cancer cell lines but not normal
A C Clark et al.
The Journal of small animal practice, 54(2), 99-103 (2012-11-14)
A 4-year-old, spayed-female great Dane was referred for surgical treatment of a suspected meningioma, diagnosed on magnetic resonance imaging 10 days prior to presentation. The suspected meningioma was removed via image-guided stereotactic craniotomy. Histopathological diagnosis was severe, locally extensive, chronic meningoencephalitis
Aileen Adam et al.
Veterinary parasitology, 177(3-4), 383-386 (2011-01-18)
On red grouse estates in the UK the nematode parasite Trichostrongylus tenuis is often controlled by application of grit medicated with the anthelmintic fenbendazole (FBZ). To date, assessment of the efficacy has been inhibited by the inability to quantify uptake
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