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224936

Sigma-Aldrich

4-(Trifluoromethyl)aniline

99%

Synonym(s):

α,α,α-Trifluoro-p-toluidine, 4-Aminobenzotrifluoride

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About This Item

Linear Formula:
CF3C6H4NH2
CAS Number:
455-14-1
Molecular Weight:
161.12
Beilstein:
1564853
EC Number:
207-236-5
MDL number:
MFCD00064396
UNSPSC Code:
12352100
PubChem Substance ID:
24853465
NACRES:
NA.22

Assay

99%

form

liquid

refractive index

n20/D 1.483 (lit.)

bp

83 °C/12 mmHg (lit.)

density

1.283 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Nc1ccc(cc1)C(F)(F)F

InChI

1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2

InChI key

ODGIMMLDVSWADK-UHFFFAOYSA-N

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Application

4-(Trifluoromethyl)aniline was used in the synthesis of 4-(trialkylmethyl)anilines. It was also used as a synthetic building block.

Signal Word

Danger

Hazard Statements

H301,H318,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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A Facile Synthesis of 4-(Trialkylmethyl) anilines by the Reaction of 4-(Trifluoromethyl) aniline with Grignard Reagents.
Synthetic Communications, 27(11), 1975-1980 (1997)
Meritxell Guinó et al.
The Journal of organic chemistry, 72(16), 6290-6293 (2007-07-13)
Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.
Tetrahedron Letters, 48, 4749-4749 (2007)
R E Cilley et al.
Journal of pediatric surgery, 35(1), 113-118 (2000-01-26)
The mechanisms by which static airway pressures in the developing lung affect development are unknown. The in vitro murine fetal lung model with airway ligation reproduces the phenomenon of intraluminal airway pressure in developing lungs. We have applied the technique
J Seifert et al.
Toxicology, 83(1-3), 49-59 (1993-10-25)
Reactive isomeric 3- and 4-trifluoromethylanilines (3-,4-TFMA), and control aniline itself, induced the following effects on biosynthesis of DNA in the liver, kidney, thymus and spleen of rats: (a) The administration of 4-TFMA initially suppressed the utilization of labeled thymidine for
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