151270
1-(2-Pyridyl)piperazine
98%
Synonym(s):
2-Piperazinopyridine
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About This Item
Empirical Formula (Hill Notation):
C9H13N3
CAS Number:
Molecular Weight:
163.22
Beilstein:
140423
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
98%
form
liquid
refractive index
n20/D 1.595 (lit.)
bp
120-122 °C/2 mmHg (lit.)
density
1.072 g/mL at 25 °C (lit.)
SMILES string
C1CN(CCN1)c2ccccn2
InChI
1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
InChI key
GZRKXKUVVPSREJ-UHFFFAOYSA-N
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Application
1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
230.0 °F - closed cup
Flash Point(C)
110 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent.
Journal of Chromatography A, 212(1), 93-104 (1981)
P Giral et al.
European journal of pharmacology, 134(1), 113-116 (1987-01-28)
We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 and 0.06 mg/kg, respectively), tests related to brain alpha-adrenergic function. Both effects were
Harvey Wong et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(8), 1387-1392 (2007-05-15)
The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distribution (2.6 +/- 0.3 l/kg), and half-life (1.2 +/- 0.2 h) of 6-OH-buspirone in rats
Tengxuan Tang et al.
Journal of fluorescence, 29(2), 445-450 (2019-02-03)
A new fluorescent sensor was designed and synthesized from 5-nitro-1,2-dihydroacenaphthylene, n-butyl amine and 1-(2-pyridyl)piperazine. In DMF/H2O (3:1, v/v), the sensor showed excellent selectivity and sensitivity to Fe3+ with fast fluorescence enhancement and good anti-interference ability. The maximal fluorescence intensity was
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