N7537

NSC 663284

≥98% (HPLC), solid

• Synonym(s): 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• Empirical Formula (Hill Notation): C₁₅H₁₆ClN₃O₃
• CAS Number: 383907-43-5
• Molecular Weight: 321.76
• MDL number: MFCD08276924
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724556
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: red
• solubility: DMSO: ≥10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• InChI key: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Gene Information: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

Description

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Biochem/physiol Actions

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): 470.1 °F
• Flash Point(C): 243.4 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves